Oncology and basic science

Cancer stem cells in basic science and in translational oncology: can we translate into clinical application?

Since their description and identification in leukemias and solid tumors, cancer stem cells (CSC) have been the subject of intensive research in translational oncology. Indeed, recent advances have led to the identification of CSC markers, CSC targets, and the preclinical and clinical evaluation of the CSC-eradicating (curative) potential of various drugs. However, although diverse CSC markers ...

Basic Facts for Basic Science

Overall, this outstanding text should soon become recognized as the definitive reference for the diagnosis and management of ocular trauma. The tall, narrow shape of Basic Facts for Basic Science suggests that perhaps the author intended that it be put into the pocket of one's lab coat; perhaps not, but this book is certainly appropriate for the shelf of any laboratory and for the office of any...

How basic is basic science?

Some other possible conclusions come easily to mind. Perhaps, if we’re really concerned about students’ learning evidence-based medicine, then we should teach it more or better. On the other hand I am one of many who have joined the anti-EBM movement (Norman 1999). In my view, the fundamental irony remains that, even though it made the BMJ’s ‘‘Top 15 Medical Innovations of all Time’’ list in 20...

Basic Science

Basic science and public policy.

I would like to address my attention to the Cancer Program as seen by the basic science community, not so much in terms of dollars and cents but of the objectives; i.e., where and how the basic sciences should fit and what role they have been asked to play in the Program. I am not going to deal with specifics of appropriation from the NCI budget, nor with the scientific basis of cancer control....